Lung adenocarcinoma is the tumor with the highest number of switch genes (298) compared to its normal tissue, followed by thyroid (227) and colorectal (183) cancers. Switch genes codifying for kinases were 14,7 and 3 respectively.We looked for three homology sequences identified across vemurafenib targets and we found that thyroid cancer and lung adenocarcinoma have a similar number of putative targetable switch genes kinase (5-6); on the contrary, colorectal cancer has just one,with minor homology sequence.
Prediction of response to vemurafenib in BRAF V600E mutant cancers based on a network approach / Falcone, R.; Paci, P.; Verrienti, A.; Fiscon, G.; Sponziello, M.; Conte, F.; Pecce, V.; Rosignolo, F.; Grani, G.; Lamartina, L.; Ramundo, V.; Durante, C.; Farina, L.; Filetti, S.. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 29:(2018), pp. viii667-viii668. [10.1093/annonc/mdy303.057]
Prediction of response to vemurafenib in BRAF V600E mutant cancers based on a network approach
Falcone R.
;Paci P.;Verrienti A.;Fiscon G.;Sponziello M.;Conte F.;Pecce V.;Rosignolo F.;Grani G.;Lamartina L.;Ramundo V.;Durante C.;Farina L.;Filetti S.
2018
Abstract
Lung adenocarcinoma is the tumor with the highest number of switch genes (298) compared to its normal tissue, followed by thyroid (227) and colorectal (183) cancers. Switch genes codifying for kinases were 14,7 and 3 respectively.We looked for three homology sequences identified across vemurafenib targets and we found that thyroid cancer and lung adenocarcinoma have a similar number of putative targetable switch genes kinase (5-6); on the contrary, colorectal cancer has just one,with minor homology sequence.| File | Dimensione | Formato | |
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